Reflections and perspectives on sacral neuromodulation in the treatment of refractory overactive bladder disorder
10.3760/cma.j.cn115396-20230531-00154
- VernacularTitle:骶神经调节在难治性膀胱过度活动症治疗中的思考和展望
- Author:
Chuan QIN
1
;
Gangyue HAO
Author Information
1. 首都医科大学附属北京友谊医院泌尿外科，北京 100050
- Keywords:
Urinary bladder;
Urinary bladder diseases;
Overactive;
Refractory overactive bladder;
Sacral neuromodulation
- From:
International Journal of Surgery
2023;50(7):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Overactive bladder (OAB) is a common urological condition. First-line treatment for OAB includes behavioral therapy as well as pharmacological treatment with M-blockers and β3-adrenoceptor agonists. Patients with OAB who fail behavioral therapy and do not achieve the desired outcome after 6-12 weeks of treatment with M receptor antagonists alone or who cannot tolerate the adverse effects of oral medications are referred to as refractory OAB. patients with refractory OAB can be treated with surgical interventions such as Sacral Neuromodulation (SNM), intravesical Botulinum Toxin type A. BTX-A and Percutaneous Tibial Nerve Stimulation. Compared with other procedures, SNM is highly effective and has a low incidence of adverse effects. The author contemplates that future studies of SNM for refractory OAB could be conducted to address the overall changes in intestinal flora-urinary flora-metabolomics and urinary control-related brain structure-spinal cord functional structure-peripheral pelvic floor nerve structure.
