Value and research progress of BRAFV600E mutation in the diagnosis and treatment of thyroid carcinoma
10.3760/cma.j.cn115396-20221227-00438
- VernacularTitle:BRAFV600E突变在甲状腺癌诊治中的价值及研究进展
- Author:
Yonghao ZHONG
1
;
Peng LIU
;
Peng GONG
Author Information
1. 深圳大学总医院普外科，深圳 518055
- Keywords:
Thyroid Carcinoma;
BRAF V600E;
Review
- From:
International Journal of Surgery
2023;50(1):67-72
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid Carcinoma, as one of the most common malignant tumors in the endocrine system and head and neck, has a rising incidence rate in the world in recent years, which seriously affects human health. Thyroid carcinoma is often divided into 4 pathological types: papillary carcinoma, follicular carcinoma, medullary carcinoma and undifferentiated carcinoma. Among them, papillary carcinoma is the most common with low malignancy and undifferentiated carcinoma is extremely rare with the highest malignancy. BRAFV600E mutation has been found to be closely related to the genesis, development mechanism and prognosis of thyroid carcinoma, and is a current molecular research focus. Clinically, BRAFV600E mutation is often considered as a molecular marker affecting the prognosis of thyroid carcinoma. In this paper, the relevant literature in recent years was reviewed, mainly from the aspects of BRAFV600E mutation and thyroid carcinoma diagnosis, clinicopathological features, guidance of clinical treatment decision, prognosis and so on, to evaluate the clinical application value of BRAFV600E mutation.
