Preparation and performance evaluation on chitosan/gelatin hydrogel hemostatic material containing Panax notoginseng
10.3760/cma.j.cn121382-20221030-00109
- VernacularTitle:含中药三七的壳聚糖/明胶水凝胶复合止血材料的制备和性能评价
- Author:
Haining ZHI
1
;
Rongjiang SHAO
;
Wei GUO
;
Chuanlin WANG
;
Ming LI
Author Information
1. 天津中医药大学第一附属医院，天津 300073
- Keywords:
Chitosan;
Gelatin;
Panax notoginseng;
Hydrogel;
Hemostatic material
- From:
International Journal of Biomedical Engineering
2023;46(1):48-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare chitosan/gelatin hydrogel composite hemostatic materials loaded with Panax notoginseng (PN/CMC/GMs) and evaluate their performance. Methods:PN/CMC/GMs hydrogel composite hemostatic material were prepared by the freeze-drying method, and their morphology was observed by scanning electron microscopy. Their rheological properties were observed by a rheometer. Their water absorption rate was tested by dissolution. Their biocompatibility was detected by a cytotoxicity assay. Their rapid hemostatic effect was tested using a SD rat liver hemorrhage model.Results:PN/CMC/GMs composite hemostatic materials were prepared in a lattice-like structure with certain porosity. With the increase in Panax notoginseng powder content, the modulus of PN/CMC/GMs increased accordingly, and the mechanical strength increased. PN/CMC/GMs have better water absorption and expansion functions, which can form compression hemostasis and concentrated blood to achieve rapid hemostasis, and have good biocompatibility. Hemostasis experiments showed that the hemostatic time and hemostatic effect of PN, CMC/GMs hemostatic materials on liver injury in rats were better than those of the blank control group. Conclusions:PN/CMC/GMs have good hemostatic effect and biocompatibility and have the potential for further research and clinical application.
