Research progress in therapeutic resistance mechanism and therapeutic strategy of cancer stem cells
10.3760/cma.j.cn121382-20220307-00408
- VernacularTitle:肿瘤干细胞治疗抵抗机制及治疗策略的研究进展
- Author:
Weidong LI
1
;
Shuling WANG
;
Chunfang HAO
;
Xiaojing GUO
Author Information
1. 天津医科大学肿瘤医院乳腺病理研究室，国家恶性肿瘤临床医学研究中心，天津市"肿瘤防治"重点实验室，天津市恶性肿瘤临床医学研究中心，乳腺癌防治教育部重点实验室，天津 300060
- Keywords:
Cancer stem cells;
Treatment resistance;
Drug resistance mechanisms;
Treatment strategies
- From:
International Journal of Biomedical Engineering
2022;45(4):328-334
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells (CSCs) are a class of cells with self-renewal, differentiation, and tumorigenic potential in tumors. It is currently believed that the resistance of CSCs to chemotherapy and radiotherapy is an important cause of tumor recurrence and metastasis. Researchers have found that related factors in many signaling pathways endow CSCs with the ability to adapt to changes in the microenvironment, including inflammatory factors, hypoxia, low pH, and a lack of nutrients. In recent years, the mechanism of CSCs' resistance to therapy has been studied, mainly including the drug efflux mediated by the ATP-binding cassette transporter, the effect of aldehyde dehydrogenase 1 (ALDH1) activity on tumor stem cells, the enhancement of DNA damage repair and degradation of reactive oxygen species, autophagy, activation of development-related pathways, stimulation of the microenvironment, and EMT. The targeting strategies for CSCs include targeting signaling pathway inhibitors, targeting multidrug resistance, DNA damage repair, ALDH, targeting the tumor microenvironment, immunotherapy, etc. In this review, the research progress in CSCs treatment resistance and related treatment strategies was reviewed.
