Expression and mechanism of KIF4A gene in renal clear cell carcinoma based on database
10.3760/cma.j.cn121382-20220123-00308
- VernacularTitle:基于数据库分析KIF4A基因在肾透明细胞癌中临床意义
- Author:
Dongsheng ZHU
1
;
Xiangfei XU
;
Ming ZHANG
;
Tong WANG
;
Hong LUO
Author Information
1. 连云港市第一人民医院小儿外科，连云港 222002
- Keywords:
UALCAN database;
Kinesin family member 4A;
Renal clear cell carcinoma
- From:
International Journal of Biomedical Engineering
2022;45(3):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between the expression and prognosis of kinesin family member 4A (KIF4A) in renal clear cell carcinoma and explore its potential mechanism.Methods:Information on the KIF4A gene in renal clear cell carcinoma was retrieved from the UALCAN database, including expression levels, survival analysis, and positive and negative correlation gene data, from which the expression levels, prognostic information, and potential mechanisms of KIF4A in renal clear cell carcinoma were derived.Results:KIF4A is highly expressed in renal clear cell carcinoma, and male patients have a higher expression rate than female patients. The higher the tumor grade and the later the N stage, the more expression ( P<0.05). The survival analysis showed that the expression level and prognosis of KIF4A were negatively correlated ( P<0.05). Cyclin B2 (CCNB2), kinesin family member 23 (KIF23), cell division cycle associated 5 (CDCA5), and KIF4A were significantly positively correlated, whereas DHRS12, crumbs protein homolog 3 (CRB3), β-hydroxybutyrate dehydrogenase 2 (BDH2), and KIF4A were significantly negatively correlated. Conclusions:KIF4A plays an important role in the development of renal clear cell carcinoma and can be used as a potential marker and therapeutic target for the diagnosis and prognosis of renal clear cell carcinoma, including in children.
