Prediction of outcomes after endovascular mechanical thrombectomy in patients with acute ischemic stroke by NIHSS score at 24 h after onset
10.3760/cma.j.issn.1673-4165.2022.10.003
- VernacularTitle:发病后24 h NIHSS评分预测急性缺血性卒中患者血管内机械血栓切除术后转归
- Author:
Linlin XIE
1
;
Meng ZHANG
;
Kun WANG
;
Xiaoyan ZHU
;
Xudong PAN
Author Information
1. 青岛大学附属医院神经内科，青岛 266071
- Keywords:
Stroke;
Brain ischemia;
Thrombectomy;
Neurologic examination;
Treatment outcome
- From:
International Journal of Cerebrovascular Diseases
2022;30(10):732-737
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of the National Institutes of Health Stroke Scale (NIHSS) score at baseline and 24 h after the onset for the outcomes after endovascular mechanical thrombectomy (EMT) in patients with acute ischemic stroke.Methods:Patients with anterior circulation large vessel occlusive acute ischemic stroke received EMT in the Affiliated Hospital of Qingdao University from July 2018 to June 2020 were enrolled prospectively. According to the modified Rankin Scale scores at 3 months after the onset, they were divided into good outcome group (0-2) and poor outcome group (3-6). The demographic and clinical data between the groups were compared. Multivariate logistic regression analysis was used to determine the independent influencing factors of clinical outcomes. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the independent influencing factors for outcomes. Results:A total of 124 patients were included. Their age was 65.23±12.40 years, 80 were males (64.5%). The baseline NIHSS score was 15 (interquartile range, 11-19). Seventy-two patients (58.1%) had a good outcome and 52 (41.9%) had a poor outcome. Univariate analysis showed that there were significant differences in age, degree of vascular recanalization, baseline and 24 h NIHSS score after onset, and whether having intracranial hemorrhage or not between the good outcome group and the poor outcome group ( P<0.05). Multivariate logistic regression analysis showed that there was a significant independent correlation between the NIHSS score at 24 h after onset and the poor outcome (odds ratio [ OR] 1.243, 95% confidence interval [ CI] 1.125-1.373; P<0.001). ROC curve analysis showed that the area under the curve of poor outcome predicted by baseline NIHSS score was 0.639 (95% CI 0.542-0.737), and the predictive sensitivity and specificity were 80.8% and 45.8% respectively. The area under the curve of poor outcome predicted by NIHSS score at 24 h after onset was 0.830 (95% CI 0.759-0.902), and the predictive sensitivity and specificity were 94.2% and 65.3% respectively. Conclusion:In patients with anterior circulation large vessel occlusive acute ischemic stroke receiving EMT, the NIHSS score at 24 h after onset has higher predictive value for poor outcomes at 3 months after onset, and is significantly better than the baseline NIHSS score.
