Progress on FUT2 gene and gut microbial composition in relation to rotavirus susceptibility
10.3760/cma.j.issn.1673-4408.2023.08.004
- VernacularTitle:FUT2基因和肠道微生物组成与轮状病毒易感性的研究进展
- Author:
Lun FANG
1
;
Junhua CHEN
Author Information
1. 重庆医科大学附属儿童医院感染科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿童感染免疫重庆市重点实验室 400014
- Keywords:
Rotavirus;
FUT2;
Histo-blood group antigen;
Gut microbes;
Susceptibility
- From:
International Journal of Pediatrics
2023;50(8):516-520
- CountryChina
- Language:Chinese
-
Abstract:
Rotavirus(RV) is currently the leading cause of severe diarrhea in infants and young children worldwide, and RV has been found to recognize and bind to histo-blood group antigens(HBGAs) through its structural protein VP8, and the FUT2 gene determines the expression of HBGAs in epithelial tissues and secretion in body fluids.Individuals with loss of functional enzyme activity due to mutations in the FUT2 gene, called non-secretors, are unable to express and secrete HBGAs in the mucosa and body fluids, and non-secretors have been found to be resistant to diarrhea caused by RV.Studies have shown that microbial composition is genetically regulated by the host, and hundreds of genetic loci are involved in regulating the composition of human gut microbes, including FUT2.Sterile animal models reduce the rate of RV infection, suggesting that intestinal bacteria are associated with the process of RV infection.These studies reveal that secretory status directly influences individual susceptibility to RV, and its effect on gut microbial composition indirectly modulates human susceptibility to RV.This article reviews the correlation between FUT2 and gut microbial composition with RV susceptibility, with the aim of opening new avenues for personalized prevention and treatment of RV infection.
