Progress of unfolded protein response in acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4408.2023.06.008
- VernacularTitle:未折叠蛋白反应在急性呼吸窘迫综合征中的研究进展
- Author:
Peilong LI
1
;
Hongmin FU
Author Information
1. 昆明市儿童医院呼吸与危重症医学科 云南省儿童重大疾病研究重点实验室 650034
- Keywords:
Endoplasmic reticulum stress;
Unfolded protein response;
Acute respiratory distress syndrome;
Signal pathway
- From:
International Journal of Pediatrics
2023;50(6):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome(ARDS)is a severe respiratory disease in children and the pathogenesis is not fully defined.It is mainly related to various mechanisms of lung injury such as inflammation and autophagy.In recent years, studies have found that, endoplasmic reticulum stress(ERS)can aggravate lung injury in ARDS, in which protein homeostasis imbalance can induce activation of the unfolded protein response(UPR).The UPR reconstructs homeostasis by mediating transmembrane protein-related signaling pathways, while continuous excessive ERS will promote apoptosis and autophagy.This review summarizes the progress of the signaling pathway of UPR related to lung injury and its inflammatory effect in ARDS.
