The advances of streptococcus pneumoniae-associated hemolytic uremic syndrome
10.3760/cma.j.issn.1673-4408.2023.05.008
- VernacularTitle:肺炎链球菌相关的溶血尿毒综合征研究进展
- Author:
Song SU
1
;
Junrong LIU
;
Hongmei QIAO
Author Information
1. 吉林大学第一医院小儿呼吸科，长春 130021
- Keywords:
Children;
Streptococcus pneumoniae;
Hemolytic uremic syndrome;
Pathogenesis;
Clinical feature;
Treatment
- From:
International Journal of Pediatrics
2023;50(5):326-330
- CountryChina
- Language:Chinese
-
Abstract:
Streptococcus pneumoniae-associated hemolytic uremic syndrome(SP-HUS) is a thrombotic microvascular disease caused by streptococcus pneumoniae infection, which is one of the causes renal failure in children.Clinical manifestations include thrombocytopenia, hemolytic anemia and acute renal failure.The neuraminidase and surface protein C substance of Streptococcus pneumoniae, immune factors and complement play important roles in the pathogenesis of SP-HUS.The complement inhibitors provides a new solution for the treatment of SP-HUS.However, few SP-HUS cases have been reported in China.This paper reviews the pathogenesis, clinical manifestations and treatment of SP-HUS to help clinicians better understand the disease, early recognition and intervention treatment.
