Advances on the correlation between hypoxia inducible factor and epigenetic modification
10.3760/cma.j.issn.1673-4408.2023.03.009
- VernacularTitle:低氧诱导因子与表观遗传修饰相关性的研究进展
- Author:
Youjia WEI
1
;
Chunmei ZHU
Author Information
1. 首都儿科研究所附属儿童医院呼吸科，北京 100020
- Keywords:
Hypoxia inducible factor;
Epigenetic regulation;
Hypoxia;
Methylation;
Lactylation
- From:
International Journal of Pediatrics
2023;50(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor(HIF)is a key factor in the regulation of oxygen homeostasis, and its expression level is mainly influenced by oxygen concentration in the adaptation of the body to chronic hypoxia, with which many pediatric diseases are closely associated.The response to hypoxia can be altered by HIF and its mediated downstream signaling pathways, in addition to epigenetic modifications such as regulation of overall methylation or histone modification levels to adapt to hypoxic environments.Previous studies have shown that the transcriptional activity and stability of HIF are interrelated with various histone modifications including methylation/demethylation, hydroxylation, deacetylation, phosphorylation, and lactylation, which makes the study of epigenetic modification correlation deserves to be explored in depth as an important potential target for regulating HIF expression levels.
