Progress on methodology of pulmonary surfactant replacement therapy in neonates
10.3760/cma.j.issn.1673-4408.2023.03.005
- VernacularTitle:新生儿肺表面活性物质替代疗法的方法学研究进展
- Author:
Yixin CHENG
1
;
Xiaoguang ZHOU
Author Information
1. 南京医科大学附属儿童医院新生儿医疗中心 210008
- Keywords:
Infant, newborn;
Pulmonary surfactant;
Respiratory distress syndrome;
Replacement therapy;
Clinical application
- From:
International Journal of Pediatrics
2023;50(3):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary surfactant(PS)is a kind of phospholipid-protein complex, whose main function is to reduce the surface tension of alveoli.Exogenous PS replacement therapy has been widely used in the clinical treatment of respiratory distress syndrome(RDS)and other diseases.The clinical application methods include preventive or rescue treatment, invasive or minimally invasive treatment, intubation-surfactant-extubation(INSURE)technology and atomization treatment, etc.Nowadays, INSURE technology has been widely accepted in clinical application, and new non-invasive drug administration methods such as thin catheter, laryngeal mask airway and atomization are being studied or adopted.In this article, the progress of methodological research on clinical application of PS in newborns in recent years is reviewed.
