Progress of genes related to persistent pulmonary hypertension of the newborn
10.3760/cma.j.issn.1673-4408.2022.12.009
- VernacularTitle:新生儿持续性肺动脉高压相关基因的研究进展
- Author:
Jing QI
1
;
Zhiliang TIAN
Author Information
1. 哈尔滨医科大学附属第二医院儿内科 150086
- Keywords:
Persistent pulmonary hypertension of the newborn;
Genes;
Genetics
- From:
International Journal of Pediatrics
2022;49(12):834-837
- CountryChina
- Language:Chinese
-
Abstract:
Persistent pulmonary hypertension of the newborn(PPHN)is a disease that seriously endangers the life of the newborn caused by one or more factors.The causes mainly include respiratory distress syndrome, meconium aspiration syndrome, infection, congenital diaphragmatic hernia, etc.The pathogenesis of PPHN is still not completely clear, and neurobiochemical, internal environment, genetics and other factors are currently recognized as influencing factors.In recent years, with the rapid development and wide application of genetic testing technology, more and more studies have shown that the occurrence of PPHN may be related to the polymorphism and/or mutation of some genes.This article reviews the research progress of six gene loci that may be related to PPHN in order to provide reference for clinical research.
