Metabolic regulation of macrophage function
10.3760/cma.j.cn115356-20221121-00331
- VernacularTitle:巨噬细胞功能的代谢调控
- Author:
Kefu WU
1
;
Guoguang ZHENG
;
Xiaotong MA
;
Yuhua SONG
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所） 实验血液学国家重点实验室 国家血液系统疾病临床医学研究中心 细胞生态海河实验室，天津 300020
- Keywords:
Macrophages;
Macrophage activation;
Metabolism;
Metabolic reprogramming
- From:
Journal of Leukemia & Lymphoma
2023;32(5):264-269
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages have plastic and diverse phenotypes and functions, and they play different roles in host defense, tissue homeostasis and repair, development, and various pathologic processes. Although the classically activated macrophage (M1) and alternatively activated macrophage (M2) phenotypes are widely accepted, most macrophages under physiologic and pathologic conditions are polarized to a continuum of states between the M1 and M2 extreme phenotype poles. In recent years, research on the regulatory mechanisms of M1 and M2 macrophages has made great progress, preliminarily elucidating the role of cellular metabolic reprogramming in macrophage polarization and the role of glycolytic enzymes in controlling inflammatory macrophages. The knowledge lays the foundation for elucidating the mechanisms in the regulation of macrophage functional phenotypes. Tumor-associated macrophages play important roles in the development of tumors. The macrophages in the microenvironment of hematologic malignancies have unique features, and a deep study on them will provide new thoughts and clues for clinical diagnosis and therapeutics.
