Research progress on ribosomal proteins and their functions in diseases
10.12206/j.issn.2097-2024.202212006
- VernacularTitle:核糖体蛋白及其在疾病中的作用
- Author:
Fangfang ZHONG
1
;
Haiyan JIANG
1
;
Junping ZHANG
1
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350100, China.
- Keywords:
ribosomal protein;
disease;
extra-ribosomal function
- From:
Journal of Pharmaceutical Practice
2023;41(9):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Ribosomal proteins (RP) are important components of ribosomes and play key roles in ribosome biogenesis and protein translation. In addition, ribosomal proteins also possess many extra-ribosomal functions, such as regulation of gene expression, cell proliferation, differentiation, apoptosis, DNA repair, and many other cellular processes. The dysfunction of RP is closely related to the occurrence and development of various diseases including blood, metabolism, cardiovascular diseases and tumors, and RP might become potential therapeutic targets for a variety of diseases. The research progress on RP, including the basic functions of RP, extra-ribosomal properties, and the connections with human diseases were reviewed and their potential as biomarkers and therapeutic targets in diseases were discussed in this paper.
