Progress in One-carbon Metabolism and Tumor Therapy
10.3971/j.issn.1000-8578.2021.20.0420
- VernacularTitle:一碳代谢与肿瘤治疗的研究进展
- Author:
Dongqi CHAI
1
;
Weixing WANG
Author Information
1. Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
One-carbon metabolism;
Tumor therapy;
Serine;
Folic acid
- From:
Cancer Research on Prevention and Treatment
2021;48(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, it has already run into a common view that "tumor is a metabolic disease", and the reprogramming of tumor metabolism has become the focus of current research. One-carbon metabolism involves folate cycle, methionine cycle and trans-sulfuration pathway. By utilizing these three ways, one carbon unit can regulate tumor growth and proliferation with the production of pyrimidine, thymidine, s-adenosine, glutathione, etc. This paper mainly describes the production and utilization of one carbon unit in tumor, as well as the interaction between one carbon metabolism and tumor development, providing new ideas for studying the mechanism of one-carbon metabolism in tumorigenesis and the treatment of nutrients in tumor.
