Application of Biomechanical Stress from Coronary Computed Tomography Angiography in Coronary Plaque Assessment and Prediction of Adverse Cardiovascular Events
10.16156/j.1004-7220.2023.03.30
- VernacularTitle:基于冠状动脉CT造影的生物机械应力在斑块评估及不良心血管事件预测中的应用
- Author:
Haotai XIE
1
;
Yan ZHANG
1
;
Yanjun GONG
1
Author Information
1. Department of Cardiology, Peking University First Hospital
- Publication Type:Journal Article
- Keywords:
coronary atherosclerotic plaque;
biomechanical stress;
CT angiography;
major adverse cardiovascular event (MACE);
computational fluid dynamics (CFD);
wall shear stress (WSS)
- From:
Journal of Medical Biomechanics
2023;38(3):E627-E634
- CountryChina
- Language:Chinese
-
Abstract:
Long-term exposure to risk factors will lead to coronary atherosclerosis, which will lead to the formation and progression of coronary plaque. Early identification of high-risk plaque characteristics will help prevent plaque rupture or erosion, thus avoiding the occurrence of acute cardiovascular events. Biomechanical stress plays an important role in progression and rupture of atherosclerotic plaques. In recent years, non-invasive coronary computed tomography angiography (CCTA) computational fluid dynamics (CFD) modeling has made it possible to acquire the corresponding biomechanical stress parameters. These coronary biomechanical stress parameters, especially wall shear stress (WSS), will aid in the development of a more accurate clinical model for predicting plaque progression and major adverse cardiovascular events ( MACE ). In this review, the biomechanical stress and the role of WSS from CCTA in atherosclerosis were introduced, and the researches on the relationship between biomechanical stress from CCTA and coronary artery diseases were discussed.
