Advances in corneal nerve regulation of ocular surface microenvironment
10.3980/j.issn.1672-5123.2023.10.08
- VernacularTitle:角膜神经调控眼表微环境的研究进展
- Author:
Ming CHANG
1
;
Xiong-Shi LIN
1
;
Shuang-Yong WANG
1
Author Information
1. Department of Ophthalmology,the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
corneal nerve;
ocular surface microenvironment;
corneal neovascularization;
neurogenic inflammation;
wound healing
- From:
International Eye Science
2023;23(10):1643-1647
- CountryChina
- Language:Chinese
-
Abstract:
The cornea is a transparent outer layer of the anterior eye segment, innervated by a high density of neural tissue. In the process of corneal innervation, trigeminal ganglion originated corneal nerves traverse different types of corneal cell in the epithelial and stromal layers. Corneal stromal cells, epithelial cells, immune cells, and other cells interact closely to maintain corneal microenvironmental homeostasis. In addition, corneal nerves is associated with the occurrence and development of many ocular surface diseases. Corneal nerves release various active peptides that regulate corneal sensation, maintain epithelial integrity and proliferation, improve wound healing, and manage local inflammation and immune response. This article reviews the advances in the corneal nerve regulation of the ocular surface microenvironment, providing some new ideas for the further study and treatment of corneal nerve-associated diseases.
