Reaserch progress of microglial phagocytosis in ischemic stroke
10.11665/j.issn.1000-5048.2023022106
- VernacularTitle:缺血性脑卒中后小胶质细胞吞噬作用的研究进展
- Author:
Heng WANG
1
;
Hao SUN
;
Hong LIAO
Author Information
1. 中国药科大学新药筛选中心 江苏省药效研究与评价服务中心
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
microglia;
phagocytosis
- From:
Journal of China Pharmaceutical University
2023;54(4):399-409
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is a major disease affecting human health, and its pathological mechanism has not been fully elucidated. Microglia are important immune cells in the central nervous system, and participate in the pathological process of ischemic stroke.Following an ischemic stroke, a surge in activated microglia occurs, migrating and congregating within the afflicted regions.These microglia engulf deceased cells or fragments, releasing inflammatory or nutritive factors, thereby participating in the pathogenesis of ischemic stroke.The phagocytosis of microglia plays an important role in cerebral ischemic injury and rehabilitation. This article summarizes the molecular mechanism of microglial phagocytosis and reviews the research progress of microglial phagocytosis in ischemic stroke, and discusses the diversity and complexity of microglial phagocytosis in cerebral ischemic injury and rehabilitation, so as to provide new ideas for the treatment and drug development of ischemic stroke.
