Sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents： a randomized controlled study
10.11886/scjsws20210428001
- VernacularTitle:舍曲林联合小剂量阿立哌唑治疗儿童青少年强迫性障碍的随机对照研究
- Author:
Hailong WU
1
;
Zhenqing ZHANG
1
;
Dali LU
1
Author Information
1. Xiamen Xianyue Hospital， Xiamen 361012， China
- Publication Type:Journal Article
- Keywords:
Sertraline;
Aripiprazole;
Children and adolescents;
Obsessive-compulsive disorder
- From:
Sichuan Mental Health
2021;34(6):529-532
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the efficacy and safety of sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents. MethodsA total of 62 cases pediatric patients aged 9~16 years who attended the outpatient clinic of a psychiatric hospital in Xiamen from June 2018 to May 2020 and met the diagnostic criteria of International Classification of Diseases， tenth edition （ICD-10） for obsessive-compulsive disorder were enrolled in the study. The selected children were randomly classified into two groups for different treatments. Control group （n=30） received sertraline monotherapy， and study group （n=32） received sertraline combined with low-dose aripiprazole treatment. At the baseline and the end of the 2nd， 4th， 8th and 12th weeks of treatment， children were assessed using Children's Yale-Brown Obsessive Compulsive Scale （CY-BOCS） and Treatment Emergent Symptoms Scale （TESS）. Thereafter， the clinical efficacy and adverse reactions were compared between two groups. ResultsThe compulsive behavior dimensional score of CY-BOCS of study group was lower than that of control group at end of the 2nd and 4th weeks of treatment （t=-2.083， -2.176， P<0.05）. At the end of the 2nd week of treatment， the effective rate was 40.63% in study group， which was significantly higher than 3.33% in control group （χ2=12.317， P<0.01）. By the end of the 12th weeks of treatment， the incidence rate of side effects yielded no statistical difference between two groups （χ2=1.608， P=0.205）. ConclusionCompared with sertraline monotherapy， its combination with low-dose aripiprazole treatment can effectively accelerate the improvement of clinical symptoms in childrenand adolescents with obsessive-compulsive disorder， while the combination therapy and sertraline monotherapy have equivalent safety.
