Pharmaceutical care for patient with schizophrenia combined with pulmonary tuberculosis： a case report
10.11886/scjsws20220507001
- VernacularTitle:精神分裂症合并肺结核患者用药监护1例
- Author:
Caiji ZHENG
1
;
Xiaodan SHEN
1
;
Yuji LI
1
Author Information
1. Shenzhen Mental Health Center/ Shenzhen Kangning Hospital， Shenzhen 518020， China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Pulmonary tuberculosis;
Clozapine;
Rifampicin
- From:
Sichuan Mental Health
2022;35(6):577-579
- CountryChina
- Language:Chinese
-
Abstract:
This paper reported a case of schizophrenia combined with pulmonary tuberculosis treated with clozapine in combination with rifampicin. Due to the induction of hepatic drug enzyme of rifampicin， plasma concentration of clozapine could not reach the effective concentration and the patient still had psychotic symptoms such as persecutory delusion. After discontinuation of rifampicin， plasma concentration of clozapine were in the effective concentration range and the patient's psychiatric symptoms improved. By analysing the therapeutic regimen for the patient with schizophrenia combined with pulmonary tuberculosis， this case suggested a possible interaction between clozapine and rifampin， and provided a reference for the treatment of this type of patients.
