Risk factors of new-onset hypertriglyceridemia in kidney transplant recipients: a single-center analysis
10.3969/j.issn.1674-7445.2023055
- VernacularTitle:肾移植受者新发高甘油三酯血症的危险因素：单中心分析
- Author:
Yuan XU
1
;
Bo YANG
1
;
Chengxin CHEN
1
;
Kejing ZHU
1
;
Yulin NIU
1
;
Haiyang LI
1
Author Information
1. Department of Organ Transplantation, the Affiliated Hospital of Guizhou Medical University, Guiyang 550000, China.
- Publication Type:OriginalArticle
- Keywords:
Kidney transplantation;
Hypertriglyceridemia;
Tacrolimus;
Blood type;
Risk factor;
Generalized estimating equation;
Mammalian target of rapamycin inhibitor;
Calcineurin inhibitor
- From:
Organ Transplantation
2023;14(5):691-699
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the risk factors of new-onset hypertriglyceridemia (HTG) in kidney transplant recipients. Methods Clinical data of 149 kidney transplant recipients were retrospectively analyzed. According to serum triglyceride (TG) level after operation, they were divided into the non-HTG group (TG≤1.7 mmol/L, n=60) and new-onset HTG group (TG>1.7 mmol/L, n=89). Baseline data of all recipients were compared between two groups. The risk factors of HTG in kidney transplant recipients were analyzed by generalized estimating equation (GEE), and validated by multiple regression equations. Results No significant differences were observed in baseline data between two groups (all P>0.05). Multivariate analysis showed that the incidence of HTG in the middle and high tacrolimus (Tac) concentration groups was higher than that in the low Tac concentration group [odds ratio (OR) 3.11, 95% confidence interval (CI) 1.22-7.93, P=0.018 in the middle Tac concentration group; OR 5.11, 95%CI 1.31-19.98, P=0.019 in the high Tac concentration group]. Compared with type-A blood recipients, the risk of new-onset HTG was significantly increased in type-O blood counterparts (OR 2.77, 95%CI 1.14-6.71, P=0.024). The risk of new-onset HTG was decreased along with the increase of preoperative globulin level (OR 0.93, 95%CI 0.87-0.99, P=0.043). At postoperative 3 months, Tac blood concentration in the new-onset HTG group was significantly higher compared with that in the non-HTG group, and significant difference was observed (P<0.05). Multiple regression equations confirmed that the risk of new-onset HTG in type-O blood kidney transplant recipients was higher than that in type-A blood counterparts, and the risk of new-onset HTG in the middle and high Tac concentration groups was higher than that in the low Tac concentration group (all P<0.05). Conclusions Type-O blood kidney transplant recipients are more prone to HTG. It is necessary to strengthen postoperative monitoring and control of blood lipids. The blood concentration of Tac probably affects the new-onset HTG in kidney transplant recipients. Maintaining an appropriate blood concentration of Tac may be beneficial to lowering the risk of HTG.
