Molecular mechanism and treatment strategy of colorectal cancer peritoneal metastasis.
10.3760/cma.j.cn441530-20230220-00047
- VernacularTitle:结直肠癌腹膜转移的分子机制和治疗策略
- Author:
Wen Qin LUO
1
;
Li YE
1
;
Guo Xiang CAI
1
Author Information
1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Colorectal Neoplasms/pathology*;
Combined Modality Therapy;
Peritoneal Neoplasms/secondary*;
Hyperthermia, Induced;
Colonic Neoplasms/therapy*;
Rectal Neoplasms/therapy*;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use*;
Prognosis;
Cytoreduction Surgical Procedures;
Survival Rate;
Tumor Microenvironment
- From:
Chinese Journal of Gastrointestinal Surgery
2023;26(5):423-428
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastatic colorectal cancer (pmCRC) is common and has been considered as the terminal stage. The theory of "seed and soil" and "oligometastasis" are the acknowledged hypotheses of pathogenesis of pmCRC. In recent years, the molecular mechanism related to pmCRC has been deeply researched. We realize that the formation of peritoneal metastasis, from detachment of cells from primary tumor to mesothelial adhesion and invasion, depends on the interplay of multiple molecules. Various components of tumor microenvironment also work as regulators in this process. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been widely used in clinical practice as an established treatment for pmCRC. Besides systemic chemotherapy, targeted and immunotherapeutic drugs are also increasingly used to improve prognosis. This article reviews the molecular mechanisms and treatment strategies related to pmCRC.
