Clinical translational research and application prospects of mesenchymal stem cells in periodontal tissue regeneration.
10.3760/cma.j.cn112144-20230329-00123
- VernacularTitle:间充质干细胞在牙周组织再生中的临床转化研究及应用前景
- Author:
Shu Juan GUO
1
;
Wei Dong TIAN
2
;
Lei ZHAO
1
Author Information
1. Department of Periodontics, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.
2. Department of Trauma and Plastic Surgery, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, Chengdu 610041, China.
- Publication Type:Journal Article
- From:
Chinese Journal of Stomatology
2023;58(7):642-649
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is an oral infectious disease that occurs in the tooth supporting tissues, which damages the soft and hard tissues of the periodontium and eventually results in tooth mobility and loss. Traditional clinical treatment can effectively control the periodontal infection and inflammation. However, as the therapeutic effect depending on the local condition of periodontal defect and the systemic factors of patients, it's hard to achieve satisfactory and stable periodontal tissue regeneration for damaged periodontal tissues. Recently, as a promising therapeutic strategy in periodontal regeneration, mesenchymal stem cells (MSC) play an important role in modern regenerative medicine. Combined with the clinical translational researches of MSC in periodontal tissue engineering and the research results of our group in the past decade, it is summarized and explained the mechanism of MSC promoting periodontal regeneration, the preclinical and the clinical transformation researches as well as the future application prospects of MSC in periodontal regeneration therapy in this paper.
