RUNX1::RUNX1T1 Fusion in Pediatric Acute Myeloid Leukemia: A description of two cases.

Author: Jill Jaime ¹ ; Ivy Mae Medalla ² ; Steffanie Charlyne Tamayo ³ ; Qareem Pido ¹ ; Francisco Tria IV ⁴ ; Ma. Luisa Enriquez ³ ; Jean Kamil Sy ¹ ; Reynaldo De Castro Jr. ¹ ; Daphne Ang ⁴
Author Information

1. Philippine Childrens Medical Center, Quezon City, Philippines
2. Eastern Visayas Medical Center, Tacloban City, Leyte, Philippines
3. St. Lukes Medical Center, Quezon City, Philippines
4. Philippine Childrens Medical Center, Quezon City, Philippines;St. Lukes Medical Center, Quezon City, Philippines
Publication Type:Journal Article
Keywords: Pediatric acute myeloid leukemia; Berlin- Frankfurt-Münster (BFM-87) protocol; l,AML 15 Medical Research Council protocol
MeSH: Next Generation Sequencing; RUNX1::RUNX1T1 fusion
From: Philippine Journal of Pathology 2023;8(1):42-48
CountryPhilippines
Language:English
Abstract: RUNX1::RUNX1T1 is a core-binding factor driving fusion gene which arises from t(8;21)(q22;q22). It is one of the most common chromosomal rearrangements in both pediatric and adult Acute Myeloid Leukemia (AML) with a reported incidence o 15% in children and young adults. There are few case reports documenting RUNX1::RUNX1T1 translocation in pediatric AML. Although this is generally associated with a favorable prognosis, we report two (2) cases of de novo pediatric AML in the Philippines harboring a RUNX1::RUNX1T1 translocation, one eventually relapsed while the other attained remission but succumbed to sepsis.
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