The prevalence of advanced liver fibrosis among patients with type 2 diabetes mellitus: A single-centre experience in Penang, Malaysia
doi.org/10.15605/jafes.038.01.08
- Author:
Xe Hui Lee
1
;
Lisa Mohamed Nor
2
;
Choon Seong Ang
1
;
Toh Peng Yeow
1
;
Shueh Lin Lim
1
Author Information
1. Penang General Hospital, Penang, Malaysia
2. Putrajaya Hospital, Wilayah Persekutuan Putrajaya, Malaysia
- Publication Type:Journal Article
- Keywords:
Advanced Liver Fibrosis;
transient elastography;
FIB-4 Index
- MeSH:
type 2 diabetes mellitus;
Non-alcoholic Fatty Liver disease
- From:
Journal of the ASEAN Federation of Endocrine Societies
2023;38(1):52-61
- CountryPhilippines
- Language:English
-
Abstract:
Objectives:This study aimed to compare the severity of COVID-19, inflammatory parameters and clinical outcomes
among patients with normal and subnormal levels of Vitamin D.
Methodology: This is a retrospective cohort study of 135 patients admitted in a tertiary hospital for COVID-19. Patients
were grouped according to their Vitamin D level. Primary outcome measure was the composite of all-cause mortality and
morbidity. Other outcome measures determined were the comparison among the groups on the severity of COVID-19
infection, changes in inflammatory parameters, length of hospital stay and duration of respiratory support.
Results:There was a significant trend of higher ICU admission, mortality (p-value= 0.006) and poor clinical outcome
(p-value=0.009) among the Vitamin D deficient group. No significant difference was found for most of the inflammatory
parameters, duration of hospital stay and respiratory support. Overall, patients with deficient, but not insufficient Vitamin
D level had 6 times higher odds of composite poor outcome than those with normal Vitamin D (crude OR=5.18, p-value=
0.003; adjusted OR =6.3, p-value=0.043).
Conclusion:The inverse relationship between Vitamin D level and poor composite outcome observed in our study
suggests that low Vitamin D may be a risk factor for poor prognosis among patients admitted for COVID-19.
- Full text:2403-Article Text-23119-1-10-20230517.pdf
