Application of Metabonomics in Substance Abuse Toxicology Research.
10.12116/j.issn.1004-5619.2019.391203
- Author:
Xiu-Ying YAN
1
;
Ping XIANG
1
;
Zhi-Guo YU
2
;
Hui YAN
1
Author Information
1. Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
2. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Review
- Keywords:
biomarkers;
forensic toxicology;
metabonomics;
review;
substance abuse;
toxic mechanisms
- MeSH:
Biomarkers;
Humans;
Metabolomics;
Proteomics;
Substance-Related Disorders
- From:
Journal of Forensic Medicine
2022;38(3):400-407
- CountryChina
- Language:English
-
Abstract:
Abstrct: Metabonomics is a relative discipline that develops after genomics and proteomics, and it is an important component of systems biology. It uses high-throughput and high-sensitivity instruments to perform qualitative and quantitative analysis of all metabolic components in specific biological samples under limited conditions and combines with multivariate statistics to analyze and process the data to obtain information about physiological, pathological or toxicological changes in organisms. In recent years, because of the complicated mechanism of substance abuse and the continuous emergence of new psychoactive substances, metabonomics is increasingly used in substance abuse research. Therefore, this article reviews the application of metabonomics of substance abuse in the toxic mechanism, the mechanism of addiction and the discovery of biomarkers.
