The expression of NGF after rat diffuse axonal injury.
- Author:
Zong-Yun CHEN
1
;
Jing-Yu WANG
;
Yong-Hong LI
Author Information
1. Department of Forensic Medicine, Wannan Medical College, Wuhu 241000, China. chenzongyun1979@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Brain Injuries/metabolism*;
Diffuse Axonal Injury/metabolism*;
Forensic Pathology;
Male;
Nerve Growth Factors/metabolism*;
Random Allocation;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Forensic Medicine
2008;24(3):172-174
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of nerve growth factor (NGF) in diffuse axonal injury (DAI) in rat.
METHODS:Eighty SD rats were used and samples were taken at 1 h, 3 h, 6 h, 12 h, 24 h, 48 h, 3 d, and 7 d after brain injury. The expressions of NGF in cerebral cortex, thalamus, cerebellum, and hippocampus were studied with immunohistochemistry and compared with normal group and sham operation group.
RESULTS:Low expression of NGF was observed in normal group and sham operation group. The expression of NGF increased 1 h after injury, peaked at 12 h, and returned to basal level at day 7.
CONCLUSION:NGF is involved in repair of DAI. The changes of NGF expression following DAI may be applied to estimate the post-injury time interval of the brain in forensic medicine.
