Forensic pathological significance of immunohistochemical study with CX43 in rats on early myocardial ischaemia.
- Author:
Li-fang JIN
1
;
Ming-fang CHEN
;
Qiang ZHENG
;
Jing-yao XU
;
Yong-hao SHEN
;
You-fa ZHU
Author Information
1. Institute of Criminal Science, Hangzhou Public Security Bureau, Hangzhou 310031 China.
- Publication Type:Journal Article
- MeSH:
Animals;
Connexin 43/metabolism*;
Disease Models, Animal;
Female;
Forensic Pathology;
Immunohistochemistry;
Male;
Myocardial Ischemia/pathology*;
Myocytes, Cardiac/metabolism*;
Myometrium/pathology*;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Staining and Labeling;
Time Factors;
Tissue Distribution
- From:
Journal of Forensic Medicine
2006;22(6):411-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore one of evidence for pathologic diagnosis of early myocardial ischaemia.
METHODS:Rats were ligated of the left coronary artery according to a previously documented technique, and heart tissue was sampled at different ischaemia time. The expression of CX43 in myocardial cell was detected by Immunohistochemistry.
RESULTS:It is showed that the distribution and amount of CX43 positive staining in each group of the myocardial ischaemia was different from that of the control group.
CONCLUSION:The changes of CX43 detected by Immunohistochemical methods may be helpful for the diagnosis of early myocardial ischaemia, but further pathologic investigation and research is necessary.
