Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes.
10.1016/j.apsb.2023.02.019
- Author:
Yi-Zheng FANG
1
;
Li JIANG
1
;
Qiaojun HE
2
;
Ji CAO
1
;
Bo YANG
1
Author Information
1. Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
2. The Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou 310018, China.
- Publication Type:Review
- Keywords:
Complex;
Deubiquitinating enzyme (DUB);
Deubiquitination;
Protein partner;
Scaffold;
Substrate specificity
- From:
Acta Pharmaceutica Sinica B
2023;13(7):2955-2962
- CountryChina
- Language:English
-
Abstract:
Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome degradation and are critical for regulating protein expression levels in vivo. Therefore, dissecting the underlying mechanism of DUB recognition is needed to advance the development of drugs related to DUB signaling pathways. To data, extensive studies on the ubiquitin chain specificity of DUBs have been reported, but substrate protein recognition is still not clearly understood. As a breakthrough, the scaffolding role may be significant to substrate protein selectivity. From this perspective, we systematically characterized the scaffolding proteins and complexes contributing to DUB substrate selectivity. Furthermore, we proposed a deubiquitination complex platform (DCP) as a potentially generic mechanism for DUB substrate recognition based on known examples, which might fill the gaps in the understanding of DUB substrate specificity.
