Pathophysiology of obesity and its associated diseases.
10.1016/j.apsb.2023.01.012
- Author:
Xin JIN
1
;
Tingting QIU
1
;
Li LI
1
;
Rilei YU
1
;
Xiguang CHEN
2
;
Changgui LI
3
;
Christopher G PROUD
4
;
Tao JIANG
1
Author Information
1. School of Medicine and Pharmacy, Ocean University of China and Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266100, China.
2. College of Marine Life Sciences, Ocean University of China, Qingdao 266100, China.
3. Shandong Provincial Key Laboratory of Metabolic Diseases, Qingdao Key Laboratory of Gout, Affiliated Hospital of Qingdao University Medical College, Qingdao University, Qingdao 266100, China.
4. Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide SA 5000, Australia.
- Publication Type:Review
- Keywords:
Adipokines;
Cardiovascular disease;
Inflammation;
Insulin resistance;
Lipid accumulation;
Liver disease;
MNK;
Obesity
- From:
Acta Pharmaceutica Sinica B
2023;13(6):2403-2424
- CountryChina
- Language:English
-
Abstract:
The occurrence of obesity has increased across the whole world. Many epidemiological studies have indicated that obesity strongly contributes to the development of cancer, cardiovascular diseases, type 2 diabetes, liver diseases and other disorders, accounting for a heavy burden on the public and on health-care systems every year. Excess energy uptake induces adipocyte hypertrophy, hyperplasia and formation of visceral fat in other non-adipose tissues to evoke cardiovascular disease, liver diseases. Adipose tissue can also secrete adipokines and inflammatory cytokines to affect the local microenvironment, induce insulin resistance, hyperglycemia, and activate associated inflammatory signaling pathways. This further exacerbates the development and progression of obesity-associated diseases. Although some progress in the treatment of obesity has been achieved in preclinical and clinical studies, the progression and pathogenesis of obesity-induced diseases are complex and unclear. We still need to understand their links to better guide the treatment of obesity and associated diseases. In this review, we review the links between obesity and other diseases, with a view to improve the future management and treatment of obesity and its co-morbidities.
