Three new sesquiterpenes from roots of Curcuma longa.
10.1016/j.chmed.2022.11.007
- Author:
Jie ZHANG
1
;
Xiaorui MA
2
;
Wei WANG
1
;
Caixia WU
1
;
Ben MA
1
;
Chong YU
1
;
Haifeng WANG
1
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Sinopharm Tongmei General Hospital, Datong 037001, China.
- Publication Type:Journal Article
- Keywords:
Curcuma longa L.;
NMR;
chemical composition;
curcumin;
sesquiterpenes
- From:
Chinese Herbal Medicines
2023;15(3):470-474
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To study the chemical constituents from the roots of Curcuma longa.
METHODS:The structures of the compounds were elucidated based on extensive spectral analysis, including 1D and 2D NMR, MS, UV, and CD analysis.
RESULTS:Two new sesquiterpene compounds (1S,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one ( 1), (1R,2R,5R,7S,8R)-2,8-epoxy-5-hydroxybisabola-3,10-dioen-9-one ( 2), and a new natural product 6-(4-Hydroxymethylphenyl)-2-methyl-hept-2-ene-4-one ( 3) together with three known compounds ar-turmerone ( 4), 2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one ( 5) and 2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one ( 6) were isolated from C. longa root extract with 95% ethanol.
CONCLUSION:In the study, three new compounds were isolated from C. longa, and their absolute configurations were determined.
