Research progress in role of exosomes exosomes in mental disorders.
10.11817/j.issn.1672-7347.2023.220379
- Author:
Jialing WU
1
,
2
;
Shansi LI
1
;
Yi ZHANG
1
,
3
Author Information
1. Medical Psychological Center, Second Xiangya Hospital, Central South University, Changsha
2. 208211161@csu.edu.cn.
3. zhangyipsy@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
central nervous system;
exosomes;
extracellular vesicle;
mental disorders
- MeSH:
Humans;
Exosomes/physiology*;
Extracellular Vesicles/physiology*;
Central Nervous System;
Mental Disorders;
Blood-Brain Barrier
- From:
Journal of Central South University(Medical Sciences)
2023;48(5):771-781
- CountryChina
- Language:English
-
Abstract:
Exosomes are a class of extracellular vesicles with a structure of lipid bilayer-membrane. In the central nervous system (CNS), exosomes can be secreted from both neurons and glial cells. Exosomes released into the extracellular matrix can freely cross the blood-brain barrier and function as crucial carriers of cellular communication and substance exchange in the CNS. Exosomes play a key role in the pathological process of mental disorders such as schizophrenia, depression, and bipolar disorder, and they have the potential to be used as a targeted carrier of antipsychotic medications. Exosomes are likely to become a new tool in the future to aid in the early prevention, accurate diagnosis, and effective treatment for people with mental disorders.
