Research progress on the nucleoside/nucleotide-loaded nanomedicines.
10.3724/zdxbyxb-2022-0701
- Author:
Zheng ZHOU
1
;
Haifang LIU
2
;
Mingzhou YE
3
Author Information
1. Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu Province, China. zzhou2022@sinano.ac.cn.
2. The Second Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Precision Diagnosis of Respiratory Infectious Diseases, Zhengzhou Key Laboratory of Precision Diagnosis of Respiratory Infectious Diseases, Zhengzhou 450000, China.
3. Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu Province, China. mzye2021@sinano.ac.cn.
- Publication Type:Journal Article
- Keywords:
Antineoplastics;
Antiviral drugs;
Nanodrug delivery system;
Nucleoside analogue;
Nucleoside drugs;
Nucleotide;
Review
- MeSH:
Nanomedicine;
Nucleosides/chemistry*;
Nucleotides;
Nanoparticles/chemistry*;
Drug Delivery Systems;
Drug Carriers
- From:
Journal of Zhejiang University. Medical sciences
2023;52(3):279-284
- CountryChina
- Language:English
-
Abstract:
Nucleoside drugs play an essential role in treating major diseases such as tumor and viral infections, and have been widely applied in clinics. However, the effectiveness and application of nucleoside drugs are significantly limited by their intrinsic properties such as low bioavailability, lack of targeting ability, and inability to enter the cells. Nanocarriers can improve the physiological properties of nucleoside drugs by improving drug delivery efficiency and availability, maintaining drug efficacy and system stability, adjusting the binding ability of the carrier and drug molecules, as well as modifying specific molecules to achieve active targeting. Starting from the design strategy of nucleoside drug nanodelivery systems, the design and therapeutic effect of these nanomedicines are described in this review, and the future development directions of nucleoside/nucleotide-loaded nanomedicines are also discussed.
