Advances in cardiovascular protection effects and mechanisms of allicin.
10.19540/j.cnki.cjcmm.20230320.601
- Author:
Ying YANG
1
;
Min LI
1
;
Hai-Yan BAO
1
;
Xin-Xia LI
2
;
Jian-Guang LI
3
Author Information
1. College of Pharmacy, Xinjiang Medical University Urumqi 830011, China.
2. College of Pharmacy, Xinjiang Medical University Urumqi 830011, China Key Laboratory of High Incidence Diseases in Xinjiang, Ministry of Education Urumqi 830011, China.
3. College of Pharmacy, Xinjiang Medical University Urumqi 830011, China Xinjiang University of Science and Technology Korla 841000, China.
- Publication Type:Journal Article
- Keywords:
allicin;
cardioprotective effects;
cardiovascular diseases;
vascular protective effects
- From:
China Journal of Chinese Materia Medica
2023;48(13):3409-3420
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases(CVD) with high morbidity and mortality pose severe threats to human life. Allicin, a main active ingredient of garlic, possesses multiple pharmaceutical activities. It not only exerts cardioprotective effects but also prevents the risk factors for CVD. Allicin exerts cardioprotective effects via a variety of mechanisms, including inhibiting oxidative stress, apoptosis, autophagy, and inflammatory responses, regulating lipid metabolism and gut microbiota, inducing hydrogen sulfide production, and dilating vessels. Despite the valuable cardioprotective effects, the instability of allicin has hindered the basic research and clinical application. This paper reviews the progress in the cardioprotective effects and mechanisms of allicin in the last decade and summarizes the methods to improve the stability of allicin. In addition, this review provides a reference for further research and development of allicin in cardiovascular protection.
