Causality between type 2 diabetes mellitus and age-related macular degeneration: a Mendelian randomization study
10.3980/j.issn.1672-5123.2023.9.30
- VernacularTitle:2型糖尿病与年龄相关性黄斑变性之间的因果关系:一项孟德尔随机化研究
- Author:
Zhao LIU
1
;
Qiu-Yuan WANG
1
;
Qian XIE
1
;
Shan-Jun CAI
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University;Guizhou Eye Hospital;Guizhou Branch of National Eye Disease Clinical Research Center;Special Key Laboratory of Ocular Diseases of Guizhou Province, Zunyi 563003, Guizhou Province, China; Zunyi Medical University, Zunyi 563003, Guizhou Province, China
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
exudative age-related macular degeneration;
atrophic age-related macular degeneration;
Mendelian randomization;
inverse variance weighted
- From:
International Eye Science
2023;23(9):1573-1577
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To analyze the causality between type 2 diabetes mellitus(T2DM)and age-related macular degeneration(ARMD)based on two-sample Mendelian randomization(MR).METHODS: T2DM and ARMD samples were extracted from the FinnGen database. Inverse variance weighted(IVW)was used as the main analysis method, MR-Egger and weighted median(WM)as supplementary methods to analyze the potential relationship between them. In addition, Cochran Q test and MR-Egger intercept were also used to analyze the sensitivity, and the P-value was used as the index of research results.RESULTS: IVW showed that T2DM was associated with the incidence of exudative ARMD(OR=1.14, 95%CI 1.01～1.28, P=0.021), but it was not significantly associated with the incidence of atrophic ARMD(OR=0.96, 95%CI 0.86～1.07, P=0.554). The results of sensitivity analysis confirmed that there was no heterogeneity and pleiotropy in this study, and the results were reliable.CONCLUSION: There is a causal relationship between T2DM and exudative ARMD. Considering the high rate of blindness caused by ARMD, it is of great significance to recognize and control the risk factors of ARMD to reduce its prevalence rate and early diagnosis and treatment.
