Pathogenesis and Traditional Chinese Medicine Prevention and Treatment Strategy of Diabetic Vascular Calcification Based on Theory of Stasis-toxin-deficiency
10.13422/j.cnki.syfjx.20231695
- VernacularTitle:基于“瘀-毒-虚”探讨糖尿病血管钙化的发病机制及中医药防治策略
- Author:
Wenting WANG
1
;
Yanfei LIU
1
;
Yiwen LI
1
;
Keji CHEN
1
;
Yue LIU
1
Author Information
1. National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine， Xiyuan Hospital of China Academy of Chinese Medical Sciences，Beijing 100091，China
- Publication Type:Journal Article
- Keywords:
diabetes mellitus;
vascular complication;
vascular calcification;
etiology and pathogenesis;
stasis;
toxin;
deficiency
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(18):183-189
- CountryChina
- Language:Chinese
-
Abstract:
Vascular complications are the primary cause of the high disability and mortality in diabetic patients. Vascular calcification is a pathological basis of diabetic vascular complications and increases the risk of adverse cardiovascular events and the difficulty of revascularization in diabetic patients. It is of great clinical value to explore the measures for prevention and treatment of diabetic vascular calcification with integrated traditional Chinese and Western medicine. This paper explores the intrinsic association of stasis， toxin， and deficiency with diabetic vascular calcification to reveal the pathogenesis of diabetic vascular calcification. Stasis and toxin are causally affected by and combined with each other； deficiency refers to the deficiency of healthy Qi and the loss of Qi and blood. The three elements are associated with the occurrence and development of blood vessel diseases. This paper proposes the evolutional law of stasis， toxin， and deficiency in traditional Chinese medicine （TCM） for diabetic vascular calcification. Specifically， diabetic vascular calcification is rooted in the stasis of meridians and collaterals， develops due to the combination of stasis and toxin， and is aggravated by middle Qi deficiency. Furthermore， this paper proposes the TCM intervention principle of activating blood， removing toxin， tonifying deficiency， and dredging collaterals for the prevention and treatment of diabetic vascular calcification. The aim is to provide a theoretical basis for clinical and translational research on the prevention and treatment of diabetic vascular calcification with integrated Chinese and Western medicine.
