Effect of interleukin-10 on experimental severe acute pancreatitis's histopathologic score in rats
- VernacularTitle:白细胞介素10对实验性重症胰腺炎病理评分的影响研究
- Author:
Jun-zhong YUE
;
Jun-zhao GU
;
Jian-guo XUE
;
Yanzhong ZHOU
- Publication Type:Journal Article
- Keywords:
interleukin-10 (IL-10), pancreatitis, amylase (AMY), histopathologic score
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(9):534-535
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore effect of interleukin-10 (IL-10) on histopathologic scores of severe acute pancreatitis (SAP) and the level of serum amylase (AMY) in rats.Methods48 female and male adult Sprague Dawley rats (200—300g) were randomly allocated into three groups: OPgroup, SAP group and IL-10 group with 16 rats in each group. SAP was made with retrograde ductal infusion of 5% sodium taurocholate solution.ResultsIn SAP and IL-10 group, there were interstitial edema, necrosis, neutrophil infiltration and interstitial hemorrhage of pancreas, more or less. At 6h and 12h after models were made, the pancreatic histopathologic score in IL-10 group (4.00±0.33 and 6.25±0.25) were significantly lower than that in SAP group (6.13±0.35 and 9.50±0.50)(P<0.01). At 6 h after models were made, the serum AMY in IL-10 group was lower than that in SAP group (P<0.05), but at 12 h there were no differences.ConclusionIn earlier period of SAP in rats, IL-10 can lower the serum AMY level, and significantly reduced pancreatic histologic score (edema, inflammation, hemorrhage, and necrosis).
