Research advances in animal models of cholestatic liver disease
10.3969/j.issn.1001-5256.2023.07.035
- VernacularTitle:胆汁淤积性肝病动物模型构建的研究进展
- Author:
Qingqing ZHANG
1
;
Ying QU
1
;
Xiaobo CAI
1
;
Lungen LU
1
Author Information
1. Department of Gastroenterology, The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
- Publication Type:Review
- Keywords:
Liver Diseases;
Cholestasis;
Disease Models, Animal
- From:
Journal of Clinical Hepatology
2023;39(7):1754-1760
- CountryChina
- Language:Chinese
-
Abstract:
Cholestatic liver diseases (CLD) are a series of diseases due to impaired bile flow and accumulation of bile acid in the liver and/or systemic circulation caused by immune, genetic, and environmental factors. The pathogenesis of CLD remains unclear and CLD is difficult to treat. As a substitute for human diseases, animal models can provide a platform for exploring the etiology and pathogenesis of the disease and finding appropriate therapeutic targets. This article reviews the current research advances in the animal models of CLD.
