Advances in research of heart organoid and its application in drug discovery
10.16438/j.0513-4870.2022-1175
- VernacularTitle:心脏类器官的研究进展及在药物发现研究中的应用
- Author:
Di WU
1
;
Shou-bao WANG
2
;
Guan-hua DU
2
Author Information
1. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai 264005, China
2. Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
heart organoid;
induced-pluripotent stem cell;
isease model;
organoids on chip;
rug screening;
rug evaluation
- From:
Acta Pharmaceutica Sinica
2023;58(4):884-890
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases are fatal threats to human health and also important fields in drug discovery. Organoid is a miniature with the structure and function similar to the organ, which is formed by the self-updating and specific differentiation of stem cells during the in vitro culture. Considering its characteristics of human origin, physical features, self-assembling and genetic stability, heart organoid has attracted much attention in the study of cardiogenesis, cardiovascular diseases modeling and related drug research. Hence, this article will review the development of heart organoids and its construction strategies, highlighting its application and prospects in drug discovery.
