Research progress of active probes targeting specific aminoacids
10.16438/j.0513-4870.2022-1265
- VernacularTitle:靶向特定氨基酸的活性探针研究进展
- Author:
Hui-lan LI
1
;
Zun-hua YANG
2
;
Yu-qi YING
2
;
Yuan-ying FANG
1
Author Information
1. National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Chinese Medicine, Nanchang 330004, China
2. College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China
- Publication Type:Research Article
- Keywords:
amino acid;
targeting;
active probe;
activity-based protein (proteomic) profiling
- From:
Acta Pharmaceutica Sinica
2023;58(6):1557-1565
- CountryChina
- Language:Chinese
-
Abstract:
Activity-based protein (proteomic) profiling (ABPP) has emerged as a key component of the broad field of chemical techniques capable of directly analyzing enzyme activity in living systems. With the deepening of research on electrophilic warheads and nucleophilic amino acids, and the continuous proposal and improvement of effective development strategies, the application of amino acid-targeting active probes in various biological systems has facilitated the identification, development of new targets in various disease contexts and discovery of inhibitors. The purpose of this review is to summarize the latest progress in the design and application of active probes targeting specific amino acids, in order to provide support for the further development of amino acid-targeted covalent inhibitordrugs.
