Research progress on the nerve damage in diabetic retinopathy
10.3980/j.issn.1672-5123.2023.8.16
- VernacularTitle:糖尿病视网膜病变神经损伤的研究进展
- Author:
Ying XIE
1
;
Yang LI
1
;
Zhi-Jun DONG
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
nerve damage;
apoptosis;
glial cells;
oxidative stress
- From:
International Eye Science
2023;23(8):1323-1327
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is the main cause of substantial visual impairment of occupational active individuals in the world, which has become one of the most common eye diseases that lead to irreversible visual impairment of the working population. Precise identification and accurate intervention of early DR lesions are of great significance to block or delay the development of this disease. Recent studies have shown that DR nerve injury occurs before retinal microangiopathy, it has a series of characteristic clinical manifestations, such as dark adaptation delay, contrast sensitivity and decreased tone discrimination. These characteristic clinical manifestations are key events in the early stage of DR, which are closely related to apoptosis, glial cell proliferation, oxidative stress, inflammation, excitotoxicity of glutamate and imbalance of neurotrophic factors. In this paper, the research progress of DR nerve damage and its related factors are reviewed in order to provide new ideas for the prevention and treatment of DR.
