Application progress in classification of puncture biopsy after kidney transplantation
10.3969/j.issn.1674-7445.2023.04.020
- VernacularTitle:肾移植术后穿刺活组织检查分类应用进展
- Author:
Shadekejiang HALINUER
1
;
Jin DONG
;
Xiongfei WU
;
Jiefu ZHU
Author Information
1. Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Kidney transplantation;
Indicative biopsy;
Protocol biopsy;
Delayed graft function;
Acute rejection;
Donor specific antibody;
Acute tubular necrosis;
Subclinical rejection
- From:
Organ Transplantation
2023;14(4):612-
- CountryChina
- Language:Chinese
-
Abstract:
Renal allograft biopsy (biopsy) remains the "gold standard" for the diagnosis of renal dysfunction after kidney transplantation. Puncture biopsy after kidney transplantation could be divided into indicative biopsy and protocol biopsy according to renal function of the patients. Indicative biopsy is mainly applied to diagnose postoperative complications of kidney transplantation, evaluate the severity of disease and guide subsequent treatment. Protocol biopsy is primarily employed to regular monitor renal allograft function of kidney transplant recipients and exclude subclinical rejection and other complications. Due to the willingness of patients and other reasons, protocol biopsy has not been widely applied in China. Currently, indicative biopsy is the main biopsy pattern. At present, the indications of puncture of indicative biopsy, the timing and necessity of puncture of protocol biopsy remain controversial. In this article, the classification of puncture biopsy after kidney transplantation and research progress on tissue biomarkers based on biopsy were reviewed, aiming to assist clinical diagnosis and targeted treatment of complications after kidney transplantation and provide reference for further improving the survival of renal allografts and recipients.
