Latest research progress on expansion of the donor pool for heart transplantation
10.3969/j.issn.1674-7445.2023.04.016
- VernacularTitle:扩大供心来源的最新研究进展
- Author:
Shun YUAN
1
;
Zhiwei WANG
Author Information
1. Department of Cardiovascular Surgery, People's Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Heart transplantation;
Heart failure;
Donor shortage;
Organ preservation;
Marginal donor heart;
Xenotransplantation;
Artificial heart;
Bioartificial heart
- From:
Organ Transplantation
2023;14(4):585-
- CountryChina
- Language:Chinese
-
Abstract:
With gradual maturity of surgical technique of heart transplantation, extensive use of immunosuppressants and the improvement of organ distribution system, the shortage of donor heart has become a bottleneck issue restricting the development of heart transplantation in clinical practice. How to expand the donor pool for heart transplantation remains to be urgently solved. In recent years, with the development of science and technology and the application of new technology, groundbreaking progresses have been made on how to expand the donor pool for heart transplantation within the transplantation community. Multiple research results have been gradually translated into clinical practice, driving the development of heart transplantation in clinical settings. In this article, the latest technologies and strategies to expand the donor pool for heart transplantation were reviewed, the roles of organ preservation technology, use of marginal donor heart, xenotransplantation, artificial heart and bioartificial heart in alleviating the shortage of donor heart were investigated, and existing challenges and future directions to expand the donor pool for heart transplantation were summarized, aiming to provide reference for subsequent development of heart transplantation in clinical practice.
