Research progress on antibacterial peptides Epinecidin-1
10.12206/j.issn.2097-2024.202108100
- VernacularTitle:抗菌肽Epinecidin-1的研究进展
- Author:
Jirong WANG
1
;
Han HAN
2
;
Li DENG
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Jingzhong Medical District, PLA General Hospital, Beijing 100820, China.
- Keywords:
antimicrobial peptides;
Epinecidin-1;
mechanism
- From:
Journal of Pharmaceutical Practice
2023;41(7):400-402
- CountryChina
- Language:Chinese
-
Abstract:
The antimicrobial peptide Epinecidin-1 is a kind of small molecule active peptides extracted from Epinephelus coioides，which serves as the first line of defense for innate immune defense system of Epinephelus coioides against various pathogens. In vitro and in vivo studies have confirmed that the antimicrobial peptide Epinecidin-1 not only exhibits broad-spectrum anti-pathogen activities (including bacteria, fungi, viruses, and parasites, etc.), but also has pharmacological activities such as immune regulation, anti-cancer and wound healing. In this paper, the relevant research on the antimicrobial peptide Epinecidin-1 in recent years were summarized, including its mechanism of action, pharmacological activities, potential limitations and application prospects , so as to provide information for further research.
