Protective effects of tumor necrosis factor-α antibody on pancreatic encephalopathy in rats
- VernacularTitle:肿瘤坏死因子α抗体对大鼠胰性脑病保护作用的实验研究
- Author:
Yan-ling YANG
;
Xiao-ping XU
;
Ke-feng DOU
;
Kaizong LI
- Publication Type:Journal Article
- Keywords:
pancreatitis, tumor necrosis factor-α(TNF-α), pancreatic encephalopathy, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2004;10(3):165-166
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the protective effects of tumor necrosis factor-α(TNF-α) antibody on pancreatic encephalopathy in rats. MethodsSixty SD rats were randomly divided into the normal control group, acute necrotizing pancreatitis induction group and TNF-α antibody treated group. Acute hemorrhage necrotizing pancreatitis model in rats were induced by retrograde injection of 5% sodium taurocholate into the pancreatobiliary duct. Serum TNF-α was detected and animals were killed 12 h after drug administration. The changes of brain water contents, leucocyte accumulation and adhesion were measured, and pathological studies of pancreas and brain were performed. ResultsIn group of TNF-α antibody treated, serum TNF-α level decreased, brain water contents and leucocytes accumulation and adhension decreased significantly than that of acute necrotizing pancreatitis induction group (P<0.05). The histopathological change of pancrea was alleviative. ConclusionTNF-α antibody can alleviate the brain damage in acute hemorrhage necrotizing pancreatitis.
