Change of Kv Channel Interacting Protein 1 and Gamma-Aminobutyric Acid-ergic Neurons in Hippocampus of Pentylenetetrazole Induced Epilepsy Rats
- VernacularTitle:钾离子通道相互作用蛋白1与γ-氨基丁酸能神经元在戊四唑致癫痫大鼠海马部位的改变
- Author:
Aihua LUO
;
Weiping LIAO
;
Tao SU
;
Weiwen SUN
;
Zhuohua ZHANG
- Publication Type:Journal Article
- Keywords:
epilepsy, Kv channel interacting protein1(KChIP1), GABAergic neuron, pentylenetetrazole, hippocampus, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(9):842-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Kv channel interacting protein 1(KChIP1)in the process of epileptic seizure and the relationship between KChIP1 and gamma-aminobutyric acid-(GABA)ergic neurons.Methods Normal female Sprague-Dawley rats were treated with pentylenetetrazole to make acute pentylenetetrazole models of epilepsy.Laser Scanning Confocal Microscope(LSCM)combined with double-labeled immunohistochemical technique was applied to observe the expression of the KChIP1 and the GABAergic neurons in the hippocampus of rats.Results The number of KChIP1-postive neurons in the hippocampus was significantly increased in the acute pentylenetetrazole model rats(P<0.05).There was no significant difference in the number of double-labled neurons(P>0.05),nor of the GABA-postive neurons between the model rats and the controls.The ratio of double-labeled neurons/total positive neurons was 63.9% in the hippocampus.Conclusion The KChIP1 might be involved in epileptogenesis of pentylenetetrazole induced seizure.The KChIP1 was associated with GABAergic neurons,whereas it may be functionally different from GABA.
