Research Progress on Protective Effect and Mechanism of Salidroside on Cerebral Ischemia Injury： A Review
10.13422/j.cnki.syfjx.20230739
- VernacularTitle:红景天苷对脑缺血损伤的保护作用及机制研究进展
- Author:
Haoqun XU
1
;
Wenjing ZHANG
1
;
Yuan LOU
1
;
Yanan JIANG
1
;
Xin YUAN
1
;
Yuan WANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine （TCM），Jinan 250355，China
- Publication Type:Journal Article
- Keywords:
salidroside;
ischemic stroke injury;
cerebral ischemia-reperfusion injury;
cell apoptosis;
blood-brain barrier;
oxidative stress;
autophagy;
nerve remodeling
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(15):256-266
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is caused by a variety of factors caused by intracerebral artery stenosis or obstruction， can lead to cerebral ischemia， hypoxia， neuronal necrosis and neurological dysfunction and other pathological injuries， with high morbidity， high disability rate， high mortality characteristics. Cerebral ischemia-reperfusion injury is the main secondary injury， which can lead to permanent disability or even death in severe cases. With the development of traditional Chinese medicine（TCM） modernization， the extraction and application of active components of TCM have been paid more and more attention. Salidroside， as the main active component of Rhodirosea， a rare Chinese medicinal herb， has been proved to fight cerebral ischemia injury by inhibiting cell apoptosis， anti-oxidative stress， reducing inflammatory response， protecting blood-brain barrier， regulating autophagy， promoting nerve remodeling and synaptic regeneration in preclinical trials. However， due to its multi-pathway， multi-pathway and multi-target action characteristics， the specific mechanism of salidroside to improve cerebral ischemia injury has not been fully elucidated. By reviewing relevant literature in the past decade， the author reviewed the mechanism of action of salidroside in the treatment of ischemic brain injury， and summarized the recent progress of its pharmacokinetic studies and safety evaluation， in order to provide theoretical basis and new research ideas for the development and clinical application of the active ingredients of traditional Chinese medicine.
