Research progress on the role of gut microbiota in ocular diseases
10.3980/j.issn.1672-5123.2023.7.18
- VernacularTitle:肠道菌群在眼病中的作用研究进展
- Author:
Jia-Yi JIANG
1
;
Pei-Rong LU
1
Author Information
1. Department of Ophthalmology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
gut microbiota;
glaucoma;
uveitis;
diabetic retinopathy;
age-related macular degeneration
- From:
International Eye Science
2023;23(7):1153-1157
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have confirmed that gut microbiota plays a pivotal role in human health. It affects multiple organ systems other than the digestive tract. The bidirectional communication between the microbiota and the human body is finely orchestrated by different systems, including the nervous, immune, and endocrine systems. Moreover, intestinal flora imbalance plays an important role in the occurrence and development of ocular diseases such as glaucoma, uveitis, diabetic retinopathy, and age-related macular degeneration. Multiple microbiota and related metabolite(involving both microbe and host)both impact ocular diseases in animal models and demonstrate striking associations in clinical studies. Therefore, modulation of gut microbiota and metabolite may be beneficial for the maintenance of ocular homeostasis and the treatment of related ocular diseases. This article reviews the recent progress in the studies on relationship between intestinal microorganisms and several common ocular diseases, providing therapeutic targets for potential translational investigations within this research field.
