Level of Fasting Plasma Glucose, True Insulin, C-peptide and Amyloid Beta-protein in Patients with Alzheimer Disease
- VernacularTitle:阿尔茨海默病患者空腹血糖、真胰岛素、C肽及β淀粉样蛋白的水平
- Author:
Weigang LIU
;
Ruizhen TIAN
;
Yaqing FENG
;
Dawei ZHAO
;
Zhenhua GUO
;
Jianhua WANG
;
Guifang LIU
;
Zhiyuan HA
- Publication Type:Journal Article
- Keywords:
Alzheimer disease, insulin, amyloid beta-protein
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(7):645-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of insulin and amyloid beta-protein (Aβ) in patients with Alzheimer disease(AD). Methods The levels of fasting plasma glucose, true insulin, C-peptide, Aβ40 and Aβ42 in 70 healthy age-matched adults and 55 patients with AD were measured and analyzed. Results No differences were observed for the levels of fasting plasma glucose between AD groups and normal group (P>0.05). The level of the true insulin and C-peptide of the moderate/severe AD group were significantly higher than that of the normal control group(P<0.05), as well aw that of the Aβ40 (P<0.05). The level of Aβ42 of the mild AD group waw significantly higher than that of the normal control group(P<0.01). Conclusion Plasma insulin and Aβ are abnormal in AD, and they are related to severity of dementia.
