A retrospective cohort study in a university hospital evaluating the effect of maternal glucose containing intravenous fluid in neonatal glycemia
10.35460/2546-1621.2018-0020
- Author:
Gelinemae G MALAZA
1
;
Elaine C CUNANAN
2
Author Information
1. Section of Endocrinology, Department of Internal Medicine, University of Santo Tomas Hospital, Manila, Philippines
2. Section of Endocrinology, Department of Internal Medicine, University of Santo Tomas Hospital, Manila, Philippines;Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines
- Publication Type:Journal Article
- Keywords:
Neonatal hypoglycemia;
Intravenous fluid
- MeSH:
Diabetes, Gestational;
- From:
Journal of Medicine University of Santo Tomas
2019;3(1):290-294
- CountryPhilippines
- Language:English
-
Abstract:
Abstract Maternal hyperglycemia during the peripartum period is highly correlated with fetal hyperinsulinemia and consequent neonatal hypoglycemia.
Liberal use of intravenous glucose therapy prior to
delivery can potentially cause maternal hyperglycemia, therefore, it is prudent to implement all preventive measures.
This study aims to determine the occurrence of neonatal hypoglycemia with intravenous glucose therapy prior to delivery in maternal diabetes mellitus.
This was a retrospective cohort study of neonates
born from diabetic mothers at the University of Santo
Tomas Hospital Clinical and Private Divisions from
January 1, 2013 to December 15, 2017. Clinical
information gathered was divided into maternal and
neonatal characteristics. Maternal intravenous fl uid
use, rate, and duration were noted; maternal and
neonatal blood glucose results were obtained.
There were 109 infants of diabetic mothers, of
which 105 were delivered as singleton and 4 from twin pregnancies. Neonatal hypoglycemia was
present in 14.68%. Comparing the risk factors, there
was a higher amount of glucose infused to the mothers whose offspring developed hypoglycemia compared to those without hypoglycemia. Statistically,
this did not demonstrate a signifi cant difference. The
rate of glucose infusion and frequency of maternal
insulin use were similar between the groups. Linear
correlation was not evident when the total glucose
infused and the rate of intravenous glucose infusion
was compared to the neonatal glucose in the fi rst
hour of life.
Based on this study, routine administration of glucose-containing intravenous fl uid did not infl uence
the incidence of neonatal hypoglycemia. It is recommended that further prospective studies be conducted.
- Full text:1 JMUST 6.pdf
